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  Indian J Med Microbiol
 

Figure 6: Hypothetical model of effect of tanshinone IIA on the microphthalmia-associated transcription factor/mitogen-activated protein kinase signaling pathways in B16F10 cells. Tanshinone IIA stimulated phosphorylation expression of melanin synthesis-related P38 and Jun N-terminal kinase mitogen-activated protein kinase signaling pathway and inhibited phosphorylation expression of ERK1/2 signaling, then enhances microphthalmia-associated transcription factor and tyrosinase protein expression.

Figure 6: Hypothetical model of effect of tanshinone IIA on the microphthalmia-associated transcription factor/mitogen-activated protein kinase signaling pathways in B16F10 cells. Tanshinone IIA stimulated phosphorylation expression of melanin synthesis-related P38 and Jun N-terminal kinase mitogen-activated protein kinase signaling pathway and inhibited phosphorylation expression of ERK1/2 signaling, then enhances microphthalmia-associated transcription factor and tyrosinase protein expression.