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   Table of Contents - Current issue
Coverpage
April-June 2021
Volume 39 | Issue 2
Page Nos. 65-114

Online since Wednesday, June 23, 2021

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EDITORIAL  

The cutaneous manifestations related to COVID-19 infection and vaccination: current aspects and future prospects p. 65
Sheng-Hsiang Ma, Hou-Ping Sytwu, Chih-Chiang Chen
DOI:10.4103/ds.ds_24_21  
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ORIGINAL ARTICLES Top

Diagnostic value of microRNA-106a-5p in patients with psoriasis and its regulatory role in inflammatory responses p. 67
Xiaolin Dr. Miao, Xinyun Tong, Jingsang Hu, Juan Wang
DOI:10.4103/ds.ds_5_21  
Background: Psoriasis is a multifactorial, recurring, and chronic inflammatory skin disease. Objectives: This study was designed to explore the potential role of microRNA-106a-5p (miR-106a-5p) in psoriasis. Methods: The expression levels of miR-106a-5p in the serum of psoriasis patients and healthy individuals were detected by quantitative real-time polymerase chain reaction. The diagnostic value of miR-106a-5p in serum was evaluated by the receiver operating characteristic (ROC) curve. The levels of interleukin-22 (IL-22), IL-17A, and tumor necrosis factor-alpha (TNF-alpha) were determined by enzyme-linked immunosorbent assay. Dual-luciferase reporter assay was used for the target gene verification. Results: The serum expression of miR-106a-5p was found to be upregulated in psoriasis patients. ROC curve showed that miR-106a-5p had high specificity and sensitivity in the diagnosis of psoriasis. The correlation between the serum expression level of miR-106a-5p and Psoriasis Area and Severity Index was positive. The relative expression levels of IL-17A, IL-22, and TNF-alpha in serum of psoriasis patients were significantly upregulated compared with that in healthy controls, and showed a positive association with serum miR-106a-5p levels. Cell experiments demonstrated that upregulation of miR-106a-5p could promote cell proliferation, and the levels of IL-22, IL-17A, and TNF-alpha were upregulated significantly in M5-induced HaCaT cells. Phosphatase and tensin homolog was proved to be the target gene of miR-106a-5p. Conclusion: Considering the novel and vital role in psoriasis progression, miR-106a-5p is expected to be a new potent target for the treatment of psoriasis. MiR-106-5p was expected to use for more immunity diseases research and therapy.
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Cutaneous manifestations of coronavirus disease in Turkey: A prospective study p. 74
Yeniay Yildiray, Pekdemir Sen Ayse
DOI:10.4103/ds.ds_17_21  
Background: Although the clinical features of coronavirus disease 2019 (COVID-19) infection are mainly based on respiratory system symptoms, different types of skin manifestations have been described in the literature. Objectives: We investigated COVID-19 cases in Kocaeli, Turkey, in a period of 3 months to identify and figure out the real burden of skin lesions associated with COVID-19 infection. Methods: A total of 266 patients who had positive results on reverse transcription–polymerase chain reaction analysis of nasopharyngeal swab for severe acute respiratory syndrome coronavirus type 2 between March 2020 and June 2020 at our region were investigated for the study. Results: A total of 266 patients was included in this study, 92 (34.6%) patients were male and 174 (65.4%) were female. The mean ± standard deviation age of the patients was 49.2 ± 18.69 (range: 18–96 years). During clinical examination, 5 (1.9%) patients demonstrated skin lesions that might be associated with COVID-19 infection. These lesions consisted of urticaria in three patients and vesicular eruption in two patients. Conclusion: Although the incidence of cutaneous manifestations was lower than expected, these symptoms are valuable clues to identify patients or asymptomatic individuals in high-risk populations. Further prospective studies in larger populations are needed to better define the real cutaneous aspect of the disease.
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CORRESPONDENCES - INFECTIONS Top

Parvovirus B19 infection simulating a vesicular exanthem associated with COVID-19 p. 79
Miguel Fernando Garcia-Gil, Juan Monte-Serrano, Alfonso Jose Pascual-Del-Riquelme, Mariano Ara-Martin
DOI:10.4103/ds.ds_61_20  
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Characteristics of the blisters of varicella-zoster viral infection on cutaneous optical coherence tomography p. 81
Wei-Yu Alex Chen, Cheng-Yi Chang, Ting-Wei Chang, Chung-Hsing (Miriam) Chang
DOI:10.4103/ds.ds_56_20  
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Atrophying pityriasis versicolor: A rare variant with review of literature p. 83
Ya-Min Chang, Po-Yuan Wu
DOI:10.4103/ds.ds_3_21  
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A case of recalcitrant tinea capitis successfully treated with fluconazole p. 85
Jong Heon Jeong, Yu J Park, Ji Y Lee, Seung H Lee, Ai-Young Lee, Jong Soo Hong
DOI:10.4103/ds.ds_8_21  
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CORRESPONDENCES - PSORIASIS Top

Long-term effectiveness and safety of ixekizumab in the treatment of 14 patients with a history of chronic erythrodermic psoriasis who failed prior secukinumab: A bicentric retrospective study p. 87
Yang Lo, Yu-Huei Huang, Tsen-Fang Tsai
DOI:10.4103/ds.ds_51_20  
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Tocilizumab-induced psoriasis in a patient with rheumatoid arthritis: A case report and literature review p. 89
Yen-Ting Chen, Chung-Hsing (Miriam) Chang
DOI:10.4103/ds.ds_57_20  
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Skin injury due to failure of an auto-injector device after injection of biologics p. 91
Yuichi Yoshida, Naomi Tani, Osamu Yamamoto
DOI:10.4103/ds.ds_11_21  
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Laugier–Hunziker syndrome with coexisting palmoplantar psoriasis p. 93
Mustafa Urun, Yildiz Gursel Urun, Nuray Can
DOI:10.4103/ds.ds_2_21  
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CORRESPONDENCES - TUMORS Top

A case of tattoo-related basal cell carcinoma in Taiwan p. 95
An-Yu Cheng, Yu-Ju Tseng
DOI:10.4103/ds.ds_54_20  
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Diverse and rare clinical manifestations of Langerhans cell histiocytosis p. 97
Pin-Hsuan Chiang, Chi-Feng Yen, I-Hsin Shih, Guan-Hua Chen, Chin-Yi Yang
DOI:10.4103/ds.ds_12_21  
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Recurrent angiolymphoid hyperplasia with eosinophilia with CCR4 expression p. 99
Kaori Nakajima, Eri Kuroda, Sora Takeuchi, Takafumi Kadono, Tomomitsu Miyagaki
DOI:10.4103/ds.ds_58_20  
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Disseminated eruption of ectopic sebaceous glands after toxic epidermal necrolysis with good treatment response to oral isotretinoin p. 101
Yu-Han Fang, Wen-Chieh Chen, Kai-Che Wei
DOI:10.4103/ds.ds_50_20  
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CORRESPONDENCES - AUTOIMMUNITY Top

Venous thromboembolism in a case with pemphigus vulgaris after infusion of rituximab plus systemic glucocorticoids and azathioprine: A possible adverse effect of rituximab? p. 103
Kuan-Jou Wu, Kai-Che Wei
DOI:10.4103/ds.ds_7_21  
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Thymoma-associated graft-versus-host disease-like erythroderma: A harbinger of poor prognosis p. 105
Chia-Hsien Yen, Jui Lan, Chao-Kai Hsu, Julia Yu-Yun Lee, Yi-Chien Yang
DOI:10.4103/ds.ds_4_21  
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An elderly female with pemphigus foliaceus possibly induced by losartan/hydrochlorothiazide p. 107
Wei-En Wang, Ro-Wei Wu, Chung-Hsing Chang
DOI:10.4103/ds.ds_9_21  
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CORRESPONDENCES - MISCELLANEOUS Top

Multiple porokeratosis developed in association with the worsening of diabetes mellitus p. 109
Toshiyuki Yamamoto, Reiko Orikasa
DOI:10.4103/ds.ds_10_21  
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Purpura annularis telangiectodes: A rare entity in pediatric age group p. 111
Miguel Fernando Garcia-Gil, Juan Monte-Serrano, Diana Pestana-Gallardo, Mar Garcia-Garcia, Mariano Ara-Martin
DOI:10.4103/ds.ds_6_21  
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Acquired unilateral nevoid telangiectasia as a novel postherpetic Wolf's isotopic response p. 113
Hao Wu, Fang Qiu, Meng-Tong Li, Ying Zhou, Yi-Ming Fan
DOI:10.4103/ds.ds_60_20  
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