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   Table of Contents - Current issue
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October-December 2020
Volume 38 | Issue 4
Page Nos. 199-264

Online since Wednesday, December 16, 2020

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ORIGINAL ARTICLE  

C-reactive protein to albumin ratio: Is a new parameter for the disease severity in patients with psoriasis vulgaris? Highly accessed article p. 199
Funda Kemeriz, Burcu Tuğrul, Sibel Çiğdem Tuncer
DOI:10.4103/ds.ds_42_20  
Background: C-reactive protein to albumin ratio (CAR) is an inflammatory marker that is considered to have prognostic value in many inflammatory diseases. Objectives: In this study, we aimed to investigate whether there is a correlation between CAR value and disease severity in patients with psoriasis. Methods: The study included 70 plaque-type psoriasis patients and 67 healthy controls. CAR value was calculated after C-reactive protein (CRP) and albumin analysis was performed, Psoriasis Area and Severity Index (PASI) scores were documented. CAR value was compared with PASI scores in patient group. White blood cell count, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, erythrocyte sedimentation rate (ESR), and mean platelet volume and CAR values were compared among these groups. We investigated the most significant parameter for disease severity. In addition, to detect relationship between CAR, disease duration and patients' age and healthy controls, correlation analysis was performed. Results: The median CAR value was found statistically significant higher in the patient group than in the control group (P < 0.001). A significant difference of median CRP, albumin, CAR (all P values are <0.001) and ESR (P = 0.024) were found among the three groups which were arranged according to the severity of the disease. Among these parameters, CAR was found as the most associated parameter with the severity of psoriasis using receiving operator characteristic analysis. Conclusion: CAR value could be a useful parameter for evaluating disease severity, management of disease activity, and follow-up strategies.
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REVIEW ARTICLE Top

Dermoscopic manifestations of nail diseases Highly accessed article p. 205
Sushmita Pradhan, Xin Ran, Siliang Xue, Yuping Ran
DOI:10.4103/ds.ds_26_20  
Nail dermoscopy in recent years has become an auxiliary noninvasive tool for the diagnosis of nail diseases. It detects the differentiating characteristics of the nail units and assesses in the management of nail diseases. Dermoscopy may not be a diagnostic tool for all nail diseases; however, it is very useful for early observation with high magnification. This article discusses the important and common dermoscopic manifestations of nail disease cases in the daily practice. Currently, the indications of dermoscopy include viral, bacterial, fungal, inflammatory, pigmented, traumatic nail diseases, nail tumors, and connective tissue disease.
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BRIEF REPORTS Top

Clinical manifestations and neurofibromatosis type 1 gene mutations of 25 patients with neurofibromatosis type 1 from 10 Chinese pedigrees p. 217
Hui Chen, Xuefei Lin, Shi Lian, Wei Zhu
DOI:10.4103/ds.ds_49_19  
This study enrolled 25 patients with neurofibromatosis type 1 (NF1) from 10 Chinese pedigrees. Sanger sequencing analysis and multiplex ligation-dependent probe amplification analysis were used to detect mutations and large fragment losses of the NF1 gene. This study identified 10 NF1 mutations, which comprised six novel and four recurrent mutations. Majority of the mutations can lead to termination codon production, which results in the synthesis of the truncated gene product neurofibromin.
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Disseminated superficial porokeratosis and disseminated superficial actinic porokeratosis: A case series of 39 patients p. 221
Yu-Tung Hsueh, Tzu-Chien Hsu, Chao-Kai Hsu, Julia Yu-Yun Lee, Chao-Chun Yang
DOI:10.4103/ds.ds_41_20  
Porokeratosis is characterized by keratotic papules or plaques with a ridge-like border. Both disseminated superficial porokeratosis (DSP) and disseminated superficial actinic porokeratosis (DSAP) manifest as numerous, small, round maculopapules with thin thread-like elevated border but differ in their distribution of lesions and the association with sunlight exposure. To analyze and compare the clinical features of DSP and DSAP, we conducted this hospital-based retrospective study. A total of 39 patients were recruited, including 19 DSP patients and 20 DSAP patients. The median age of diagnosis of DSP and DSAP patients was 63 years and 59 years, respectively. A male predominance was noted in DSP, while a female predominance was noted in DSAP. Itchiness was the most common symptom in both subtypes. Commonly used treatments included corticosteroids and retinoids, both topical and oral. Among the treatments, oral retinoid, diclofenac gel, and cryotherapy showed higher rates of improvement, but none of them yielded complete remission of the skin lesions. In conclusion, DSP and DSAP showed differences in the gender predilection, and both DSP and DSAP had prolonged clinical course and generally refractory to topical or systemic treatments.
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CASE REPORTS Top

A rare case of tumid lupus erythematosus with unilateral linear distribution in a young child p. 225
Gwang Hoon Kim, Jong Heon Jeong, Jong Soo Hong, Seung Ho Lee, Ai-Young Lee
DOI:10.4103/ds.ds_13_20  
Tumid lupus erythematosus (TLE) as a rare variant of cutaneous lupus erythematosus (CLE) is characterized by edematous, urticarial-like annular papules and plaques. TLE has similar histopathologic findings to CLE such as periadnexal lymphocytic infiltration and interstitial mucin deposition. Although TLE develops on sun-exposed areas at any age, it is rarely distributed along the Blaschko lines and develops in infancy and childhood. Unlike CLE, skin lesion of TLE heals without leaving scarring or dyspigmentation. Here, we report a rare case of unilateral linear TLE in a 4-year-old girl, which was improved by intralesional corticosteroid injection and oral antimalarial drug with leaving postinflammatory hyperpigmentation.
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Vohwinkel syndrome associated with a p.Gly59Arg missense mutation in GJB2 p. 228
Paul-Chen Hsieh, Chen-Chi Wu, Ni-Chung Lee, Jung-Hsien Hsieh, Yi-Hua Liao
DOI:10.4103/ds.ds_14_20  
Vohwinkel syndrome is a rare autosomal dominant disease caused by GJB2 mutations. Patients present with sensorineural deafness, pseudoainhum, stellate keratosis on knuckles, and diffuse honeycombed palmoplantar keratoderma. We present a case of a Taiwanese patient with characteristics of Vohwinkel syndrome. A heterozygous missense mutation c.175G > C (p.Gly59Arg) was identified in the GJB2 gene, encoding the gap junction protein connexin 26. Pathogenic GJB2 mutations have been implicated in a spectrum of diseases from nonsyndromic hearing loss to syndromic hearing loss with palmoplantar keratoderma. This report expands the phenotypic spectrum of the p.Gly59Arg mutation to include Vohwinkel syndrome.
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Terra firma-forme dermatosis involving the genitalia: Three pediatric case reports p. 232
Hsiao-Yu Li, Hsiu-Chin Chen, Yu-Hung Wu
DOI:10.4103/ds.ds_21_20  
Terra firma-forme dermatosis is a rare acquired keratinization disorder. Patients present with dirt-like brownish plaques on the neck, trunk, and limbs. It is often confused with dermatitis neglecta, confluent and reticulated papillomatosis, and acanthosis nigricans. Reportedly, it affects children, but genital involvement is rare. We describe three cases of uncircumcised boys with genital involvement, two of which had extragenital involvement. They all had good hygiene. Two underwent skin biopsy, and pathological examination showed papillomatosis and alternating keratinization in the stratum corneum. The disease can be diagnosed clinically by wiping off the lesions with 70% isopropyl alcohol pads, instead of water or soap.
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Stevens–Johnson syndrome and toxic epidermal necrolysis related to immune checkpoint inhibitors: Two cases and literature review p. 236
Ting-Jung Hsu, Kwei-Lan Liu
DOI:10.4103/ds.ds_24_20  
Immune checkpoint inhibitor-related Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) were rarely reported. We summarized the courses and the characteristics of two cases. The first case was a 74-year-old woman receiving pembrolizumab for Stage 2 urothelial cell carcinoma of the bladder. SJS developed 27 days after the first dose of pembrolizumab. The other case was a 67-year-old woman receiving atezolizumab for Stage 4 renal urothelial cell carcinoma. TEN developed after the eighth cycle of atezolizumab. Both patients were treated with low-dose corticosteroid and supportive management. Their wounds healed without dermatologic sequelae.
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CORRESPONDENCES Top

Cutaneous cryptococcoma in association with CD4 lymphocytopenia: A patient with multiple sclerosis treated with fingolimod p. 240
Tzu-Kun Lo, Julia Yu-Yun Lee
DOI:10.4103/ds.ds_15_20  
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Cutaneous clear cell sarcoma mimicking xanthogranuloma: A diagnostic pitfall Highly accessed article p. 242
Chung-Hao Hsu, Chi-Shun Yang, Chung-Yang Yen
DOI:10.4103/ds.ds_17_20  
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Effectiveness of restoring vitamin B12 levels in the resolution of a case of erythema nodosum p. 244
Maria Maddalena Sirufo, Lia Ginaldi, Luca Morelli, Azzurra Irelli, Massimo De Martinis
DOI:10.4103/ds.ds_16_20  
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A case of lung cancer presenting with erythema nodosum p. 246
Yun Fu, Ching-Chi Chi
DOI:10.4103/ds.ds_22_20  
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Bilateral auricular ossificans with stenosis of external ear canals and hearing loss caused by primary hyperparathyroidism: A case report p. 248
Tzu-Kun Lo, Chao-Kai Hsu, Su-Ting Hsin, Jiunn-Liang Wu, Julia Yu-Yun Lee
DOI:10.4103/ds.ds_23_20  
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Radiotherapy for invasive extramammary Paget's disease: A case report p. 250
Jia-Di Lin, Dai-Wei Liu, Ming-Hsun Li, Chung-Hsing Chang
DOI:10.4103/ds.ds_18_20  
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Case of a Taiwanese patient with granuloma faciale improved with colchicine p. 252
Ya-Tang Yang, Yang Lo, Chen-Yu Wu, Shiou-Hwa Jee, Hsien-Ching Chiu, Yi-Teng Tseng
DOI:10.4103/ds.ds_30_20  
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Cutaneous adult T-cell leukemia/lymphoma mimicking primary cutaneous anaplastic large-cell lymphoma p. 254
Mariko Takaoka, Tomonori Takekoshi, Maasa Kobayashi, Rina Nakajima, Hiroaki Asai, Makoto Sugaya
DOI:10.4103/ds.ds_29_20  
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Fiberglass (glass wool) dermatitis: Rapid diagnoses using simple polarized microscope p. 256
Connie Liu, Mei-Ju Ko, Ruey-Yi Lin, Meng-Sui Lee
DOI:10.4103/ds.ds_28_20  
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Psoriasis vaccinalis p. 258
Pei-Rong Gao, Yu-Huei Huang, Chau Yee Ng
DOI:10.4103/ds.ds_35_20  
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Kaposi's varicelliform eruption after chemotherapy p. 260
Sungjun Choi, Soo Ick Cho, Dong-Wan Kim, Dong Hun Lee
DOI:10.4103/ds.ds_36_20  
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Google search trend of the keywords of “hand eczema, itchy face, acne, and dermatologist” after the COVID-19 outbreak p. 262
Wen-Chien Tsai, Kwei-Lan Liu
DOI:10.4103/ds.ds_37_20  
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Corrigendum: Skin manifestation and diagnosis of febrile diseases by COVID-19 and other ribonucleic acid viruses: The diagnostic clues p. 264

DOI:10.4103/1027-8117.303706  
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AUTHOR INDEX Top

Author Index  
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KEYWORD INDEX Top

Keyword Index  
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TITLE INDEX Top

Title Index  
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