|Year : 2022 | Volume
| Issue : 3 | Page : 127-128
Next-generation bioinformatics in dermatology research
Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan
|Date of Submission||01-Sep-2022|
|Date of Acceptance||01-Sep-2022|
|Date of Web Publication||29-Sep-2022|
Prof. Yi-Ju Chen
Department of Dermatology, Taichung Veterans General Hospital, No. 1650 Taiwan Boulevard Sect. 4, Taichung 40705
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Chen YJ. Next-generation bioinformatics in dermatology research. Dermatol Sin 2022;40:127-8
The rapid growth of metagenomic data from the next-generation bioinformatics analyses facilitates the understanding of the genes, host-microbe interactions, associated signaling pathways, and genetic functional networks within the pathogenesis of diseases. An alteration of the skin microbiome in chronic inflammatory skin diseases has been considered an emerging target for disease management. However, little is known about its role in skin aging and esthetic medicine. In this issue of Dermatol Sinica, Weng and Chen reviewed emerging perspectives on the role of the skin microbiota in acne vulgaris, skin aging, and rosacea from studies using 16s rRNA and metagenomics analyses, and suggested the potential development of therapies targeting the pathogenic strains of the skin microbiome involved in these skin problems. Zhang identified several immune-associated genes associated with signal transduction, inflammatory response, immune response, and innate immune response in atopic dermatitis, contact dermatitis, and psoriasis, by single-sample gene set enrichment analysis and gene ontology biological process. These immune-associated genes, such as FCGR3A, CD86, and CSF1R, might be considered therapeutic targets for patients with these inflammatory skin diseases. Moreover, Lu identified a novel autosomal dominant inherited mutation of KRT10, instead of a known KRT17, in a familial steatocystoma multiplex.
Female pattern hair loss (FPHL) and alopecia areata (AA) are the common causes of alopecia. The clinical relevance of systemic comorbidities in both diseases and protocol of management are not standardized. In this issue of Dermatol Sinica, Wang reported an increased rate of comorbid laboratory abnormalities in FPHL. Coexisting zinc deficiency, iron depletion, and thyroid abnormalities were commonly seen in individuals with FPHL. Younger patients (<50 years) had a higher rate of iron deficiency than in the older age group. Otherwise, Lu reported a satisfactory but temporary effect after three monthly corticosteroid pulse therapy in those with severe AA. Patients with a shorter duration of AA (≤6 months) had a significantly better response to corticosteroid pulse therapy.
Finally, in this issue of Dermatol Sinica, two rare cases of papuloerythroderma of Ofuji (PEO) with different presentations were reported in this issue. Wang reported that a PEO patient presented the paraneoplastic syndrome of lung cancer and died after 1 year of chemotherapy. Otherwise, Egawa and Kabashima reported a losartan potassium/hydrochlorothiazide-induced PEO case that was resolved after discontinuing the drug.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Weng YC, Chen YJ. Skin microbiome in acne vulgaris, skin aging, and rosacea: An evidence-based review. Dermatol Sin 2022;40:129-42. [Full text]
Zhang L, Wang HL, Tian XQ, Liu WL, Hao Y, Gao L. Identification of immune-related genes in atopic dermatitis, contact dermatitis, and psoriasis: A bioinformatics analysis. Dermatol Sin 2022;40:162-7. [Full text]
Lu KL, Wang CW, Chung WH, Wang FY. A novel mutation in keratin 10 passed down in a family with familial steatocystoma multiplex. Dermatol Sin 2022;40:188-9. [Full text]
Wang HJ, Yeh JW, Chang YF, Wu JS, Yang CC. Comorbid laboratory abnormalities in female pattern hair loss patients. Dermatol Sin 2022;40:174-7. [Full text]
Lu HA, Yang CC, Chen YC. Three monthly doses of corticosteroid pulse therapy yields a satisfactory but temporary response in severe alopecia areata patients. Dermatol Sin 2022;40:178-81. [Full text]
Wang WY, Su YC, Lan CC, Chiu SH. Papuloerythroderma of Ofuji as a paraneoplastic phenomenon in a patient with lung cancer. Dermatol Sin 2022;40:182-3. [Full text]
Egawa G, Kabashima K. A case of papuloerythroderma of Ofuji possibly associated with a combination drug of losartan potassium/hydrochlorothiazide. Dermatol Sin 2022;40:184-5. [Full text]