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CASE REPORT
Year : 2019  |  Volume : 37  |  Issue : 3  |  Page : 154-156

A case with psoriasis-like lesions induced by olmutinib (HM61713) while treating epidermal growth factor receptor T790M mutant advanced lung adenocarcinoma


1 Department of Dermatology, Chung Shan Medical University Hospital; School of Medicine, Chung Shan Medical University, Taichung, Taiwan
2 Department of Dermatology, Chung Shan Medical University Hospital; Institute of Biochemistry, Microbiology, and Immunology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan
3 Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan
4 Department of Dermatology, Chung Shan Medical University Hospital; Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan
5 Institute of Medicine, School of Medicine, Chung Shan Medical University; Department of Internal Medicine, Division of Chest Medicine and Medical Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan

Correspondence Address:
Dr. Ming-Fang Wu
Department of Internal Medicine, Division of Chest Medicine and Medical Oncology, Chung Shan Medical University Hospital, Taichung
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ds.ds_44_18

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Olmutinib (HM61713) is a third-generation tyrosine kinase inhibitor active against mutant EGFR, including T790M in nonsmall cell lung cancer. The most common side effect of olmutinib to date includes diarrhea, rash, nausea, and pruritus. To the best of our knowledge, it is the first case of psoriasis-like lesions that occurred after treatment with olmutinib. Although the pathogenesis for skin manifestations is presently unknown, we present this case to increase awareness of this unique cutaneous side effect.


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