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ORIGINAL ARTICLE
Year : 2019  |  Volume : 37  |  Issue : 2  |  Page : 67-71

The role and relationship of the serum D-dimer level and autologous serum skin test response in chronic spontaneous urticaria


Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea

Correspondence Address:
Dr. Eun Joo Park
Department of Dermatology, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 Beon-gil, Dongan-gu, Anyang, Gyeonggi-do, 431-796
Korea
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ds.ds_13_18

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Background: The severity of chronic urticaria(CU) may be associated with the D-dimer level, and CU patients often have other autoimmune disorders. The autologous serum skin test(ASST) is believed to identify autoimmune/autoreactive diseases in CU patients. Aim: This study evaluated whether the levels of D-dimer, total immunoglobulin E(IgE), and autoimmune markers, such as antithyroid peroxidase(TPO) and antithyroglobulin(TG), differ between ASST-positive and ASST-negative patients among CU patients. In addition, the study assessed whether these laboratory findings were related to CU severity. Methods: The study enrolled 54 adults with CU (16 ASST positive, 38 ASST negative). D-dimer, total IgE, autoimmune marker(anti-TPO and anti-TG), and thyroid hormone levels and the urticaria activity score(UAS) were measured. Results: The levels of D-dimer, total IgE, anti-TPO, and anti-TG and the thyroid function test result showed no difference between the ASST-positive and ASST-negative groups. The UAS was higher in the ASST-positive group than in the ASST-negative group, but the ASST-positive group showed a better treatment response. The UAS was higher in patients with an elevated D-dimer level than in those with a normal level. Total IgE was related to the UAS in only the ASST-negative group, and anti-TPO and anti-TG levels were not related to the UAS. Conclusions: There were no associations between the ASST response and the D-dimer level, total IgE level, thyroid function test results, and thyroid autoantibody levels. However, our findings suggest that the ASST response, D-dimer level, and total IgE level are potential predictors of CU severity.


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